National Institutes of Health – NIA / Alzheimer’s Database

National Institutes of Health – NIA / Alzheimer’s Database

WebFirst created the NIH/National Institutes on Aging’s AlzPED (Alzheimer’s Preclinical Efficacy Database) web-based information portal. One of the major challenges to the successful development of drugs to treat Alzheimer’s Disease (AD) is the poor translation of preclinical efficacy from AD models to the clinic. To mitigate this challenge and increase the translation to the clinic, the National Institute on Aging (NIA) together with WebFirst created a data repository containing information relating to the preclinical testing of candidate therapeutic agents in AD animal models.  The portal will house, share and provide the ability to mine published and unpublished study information with links to PubMed.  The database uses knowledge management and data visualization techniques that will help researchers gain more insight into pre-clinical trial data. Researchers are invited to upload their research studies (study goals, therapy types, outcomes, etc.) to the repository. They can then tag these studies using a taxonomy, which is curated by the curation team (PhD Neuroscientists) before being published to the database (workflow).  By inviting the community, WebFirst has helped to create a robust knowledge management system that includes innovative search engine technology, taxonomy using low cost open source platform (Drupal) as a basis.

Technologies and Techniques: Drupal 7, Apache Solr, UX/UI, User-Centered Design, Workflow

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